Phenotypes Associated with This Genotype

Genotype
MGI:5790711

• Allelic Composition: Tg(Prnp-HTRA2*G399S)1Olri/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial physiology ( J:229160 )

• mitochondria exhibit a higher basal respiration rate and state III respiration rate compared to controls, which, in combination with a slightly higher state IV respiration rate, results in a mild respiratory phenotype where spare respiratory capacity is reduced

• mitochondrial membrane potential in cells isolated from brains is about 35% lower than in wild-type mice, although this is not statistically significant

behavior/neurological

behavior/neurological phenotype ( J:229160 )

N • mice exhibit normal balance and motor coordination