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Phenotypes Associated with This Genotype
Genotype
MGI:5790338
Allelic
Composition
Scn9atm1Dgen/Scn9atm1Dgen
Genetic
Background
either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn9atm1Dgen mutation (1 available); any Scn9a mutation (120 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: most mice on a mixed BALB/c background die before P14 while most mice on a mixed CD-1 background die before P20 compared to complete neonatal lethality of mice on a congenic C57BL/6 or BALB/c background
• Background Sensitivity: mice on either a mixed BALB/c or CD-1 background show an approximate 20% survival rate to adulthood when neonates are nurtured (by hand feeding, by receiving supplementary dextrose injections when dehydrated, and by culling litters to prevent competition for resources)

growth/size/body
• neonates are smaller than wild-type mice, however mice that survive to adulthood show normal body size

behavior/neurological
• in the tail-clip assay, mutants are insensitive to mechanical hyperalgesia and do not react to a clip placed on the tail
• however, mice show unchanged tactile sensitivity measured with von Frey fibers
• mice lack a response to histamine, showing few to no scratching bouts in response to histamine injection, although a classic flare response at the injection site is seen
• 24 hours after injection of complete Freunds adjuvant into the paw, mutants do not develop thermal hyperalgesia at any time point measured in the Hargreaves apparatus as seen in controls
• mice do not respond to nociceptive stimuli
• however, mice exhibit normal overall locomotion and rearing
• mice exhibit reduced responses in both phases of the formalin pain assay, with licking and lifting in phase I of the formalin response being about 80% less in mutants and little to no licking and lifting was seen in phase II
• mice treated with veratradine or grayanotoxin III show reduced lifting and licking response, with an 85% and 96% lower response, respectively, than controls indicating that mice are insensitive to pain resulting from activation of peripheral sodium channels
• in the hot plate test, latency to withdrawal at each temperature is longer in mutants and mice do not display painful behaviors
• in the Hargreaves apparatus, mutant mice react with an approximate 40% increase in latency time compared to controls
• 24 hours after injection of complete Freunds adjuvant into the paw, mutants do not develop thermal hyperalgesia at any time point measured in the Hargreaves apparatus as seen in controls

immune system
• Background Sensitivity: in the early stages of production where F1 and F2 mice are bred, mice often show dermatitis

integument
• Background Sensitivity: in the early stages of production where F1 and F2 mice are bred, mice often show dermatitis

nervous system
• C-fiber spontaneous action potential frequency is 6-fold lower in saphenous nerve
• C-fiber action potential frequency is reduced in response to mechanical stimuli at the higher spiking rates evoked by stronger stimulus
• mice show reduced tetrodotoxin-sensitive sodium current recorded from sensory neuron cell bodies

renal/urinary system
• Background Sensitivity: in the early stages of production where F1 and F2 mice are bred, some mice, mainly males, present with urinary issues such as prolapses and blockage

taste/olfaction
• in a buried food assay, 18 of 19 mice do not find the hidden food pellet


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory