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Phenotypes Associated with This Genotype
Genotype
MGI:5790177
Allelic
Composition
Sfrp4tm1.1Blan/Sfrp4tm1.1Blan
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp4tm1.1Blan mutation (0 available); any Sfrp4 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• the number of osteoclasts is increased along the diaphyseal endocortical surface
• however, number of osteoclasts is normal in trabecular bone
• in 8 day growing mice, the number of osteoclasts along the endosteum is increased
• width of bones at the midshaft is increased
• thin cortical bone in femora and tibiae in 2 week old mice
• thin cortical bone in the calvaria
• treatment with a sclerostin-neutralizing antibody increases cortical bone thickness
• decrease in cortical bone formation
• rates of periosteal and endocortical mineral apposition are equally reduced
• increase in bone-formation rates
• failure of bone remodeling during growth
• increase in endocortical bone resorption
• reduction in mechanical strength measured at the diaphysis

hematopoietic system
• the number of osteoclasts is increased along the diaphyseal endocortical surface
• however, number of osteoclasts is normal in trabecular bone
• in 8 day growing mice, the number of osteoclasts along the endosteum is increased

immune system
• the number of osteoclasts is increased along the diaphyseal endocortical surface
• however, number of osteoclasts is normal in trabecular bone
• in 8 day growing mice, the number of osteoclasts along the endosteum is increased

limbs/digits/tail


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory