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Phenotypes Associated with This Genotype
Genotype
MGI:5789334
Allelic
Composition
Tg(SFTPC-EGFR*L858R)4-3Kkiu/0
Genetic
Background
involves: C57BL/6Cr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at about 30 weeks of age

neoplasm
• mice develop lung tumors after 7 weeks of age
• treatment of 3 week old mice with gefitinib prevents lung tumorigenesis completely
• one week after stopping gefitinib treatment of mice that had been treated with it for 15 weeks, reexpansion of tumors cells is seen
• bronchioloalveolar carcinoma at 4-5 weeks of age
• at 7 weeks of age, adenocarcinoma with solid features is seen similar to human adenocarcinoma
• however, metastatic lesions are not seen in any other organ

respiratory system
• mice develop lung tumors after 7 weeks of age
• treatment of 3 week old mice with gefitinib prevents lung tumorigenesis completely
• one week after stopping gefitinib treatment of mice that had been treated with it for 15 weeks, reexpansion of tumors cells is seen
• bronchioloalveolar carcinoma at 4-5 weeks of age
• at 7 weeks of age, adenocarcinoma with solid features is seen similar to human adenocarcinoma
• however, metastatic lesions are not seen in any other organ

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lung cancer DOID:1324 OMIM:211980
OMIM:608935
OMIM:612571
OMIM:612593
OMIM:614210
J:152157


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory