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Phenotypes Associated with This Genotype
Genotype
MGI:5787933
Allelic
Composition
Emg1tm1.1Btr/Emg1tm1.1Btr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emg1tm1.1Btr mutation (0 available); any Emg1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• open cranial neural tubes in half of mice at E10.5 to E12.5
• in some embryos
• however, the spinal neural tube closes by E12.5
• in one of two mice recovered at E12.5
• less extensive at E11.5 and E12.5 with fewer fetal red blood cells
• however, placenta is normal at E9.5

nervous system
• open cranial neural tubes in half of mice at E10.5 to E12.5
• in some embryos
• however, the spinal neural tube closes by E12.5
• in one of two mice recovered at E12.5
• collapsed telencephalic vesicle in one of two mice recovered at E12.5
• in one of two mice recovered at E12.5

cellular
• in E7.5 to E9.5 embryos
• in E7.5 to E9.5 embryos

growth/size/body

hematopoietic system
• fewer fetal red blood cells at E11.5 and E12.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Bowen-Conradi syndrome DOID:0050684 OMIM:211180
J:230556


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory