About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5787605
Allelic
Composition
Aspadeaf14/Aspadeaf14
Genetic
Background
BALB/c-Aspadeaf14
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aspadeaf14 mutation (0 available); any Aspa mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit normal Y maze and light-dark test behavior
• in response to white-noise pulses up to 115 dB sound pressure level
• Parkinson-like by age 280 days
• suggested by movement in an open field (more motion covering less distance)
• shorter latency to falling off a rotating rod
• in an open field, mice move more but cover less distance compared with wild-type mice

nervous system
• in layer V of the frontal and anterior parietal cerebral cortex, the dorsolateral aspects of the caudate-putamen, the lateral septal nuclei, the thalamus, the pyramidal cell layer of CA1, CA2 and CA3 regions of the hippocampus
• the cerebellar Purkinje cell layer is affected in some areas
• however, not the granule cell layer of the dentate gyrus, the mammillary and supramammilary nuclei, anterior pretectal nuclei, suprageniculate thalamic nuclei, medial geniculate nuclei, intermediate layers of the superior colliculi, periaqueductal nuclei, inferior colliculi, ventral cochlear nuclei, vestibular nuclei, parabrachial nuclei, dorsal tegmental nuclei, and cerebellar white matter
• in layer V of the frontal and anterior parietal cerebral cortex, the dorsolateral aspects of the caudate-putamen, the lateral septal nuclei, the thalamus, the pyramidal cell layer of CA1, CA2 and CA3 regions of the hippocampus
• the cerebellar Purkinje cell layer is affected in some areas
• however, not the granule cell layer of the dentate gyrus, the mammillary and supramammilary nuclei, anterior pretectal nuclei, suprageniculate thalamic nuclei, medial geniculate nuclei, intermediate layers of the superior colliculi, periaqueductal nuclei, inferior colliculi, ventral cochlear nuclei, vestibular nuclei, parabrachial nuclei, dorsal tegmental nuclei, and cerebellar white matter

hearing/vestibular/ear
• abnormal shape in response to mixed frequency (click) stimuli
• reduced amplitude of later peaks at 50 dB SPL
• in response to mixed frequency (click or pure-tone) stimuli at 16 kHz
• increased latency of peaks II, III, IV and V of first five clicks
• however, mice exhibit normal response to other frequencies (click) and peak I rate of peak amplitude increase with stimulus intensity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Canavan disease DOID:3613 OMIM:271900
J:211825


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/23/2021
MGI 6.16
The Jackson Laboratory