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Phenotypes Associated with This Genotype
Genotype
MGI:5776377
Allelic
Composition
Shank3tm3.1Gfng/Shank3tm3.1Gfng
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm3.1Gfng mutation (1 available); any Shank3 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• impaired motor learning as observed in rotarod test
• decreased total distance travelled in open field test as compared to controls
• mice spend less time exploring center of open area test than controls
• mice spend less time in open arm during elevated zero maze test
• 28% of mice develop lesions from grooming between 4 and 6 months
• mice spend twice as much time grooming as controls
• impaired acoustic startle response
• impaired motor coordination in rotarod test
• reduced number of interactive events in juvenile social play at P23
• nose-to-anogenital sniffing and following behavior are reduced as compared to controls
• increased social dominance behavior as determined by tube test
• mice exhibit no preference for a stranger mouse or novel object in a test of voluntary social interaction

nervous system
• reduction in spine density of layer 2/3 pyramidal neurons in prefrontal cortex
• reduced field population spike amplitude in dorsolateral striatum at P14 and adult as compared to controls
• presynaptic function is not affected
• reduced NMDA receptor-mediated currents as compared to controls
• increase in mEPSC amplitude in P14 dorsolateral striatal medium spiny neurons, but not frequency, as compared to controls
• no difference in mEPSC frequency or amplitude is found in prefrontal cortex of P14 mice
• reduced mEPSC frequency in medium spiny neurons from adult mice as compared to controls
• small, but significant, reduction of mEPSC amplitude in medium spiny neurons from adult mice as compared to controls
• reduced paired pulse inhibition (PPI)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory