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Phenotypes Associated with This Genotype
Genotype
MGI:5776354
Allelic
Composition
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm5.1Gfng mutation (1 available); any Shank3 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decreased total distance travelled in open field test as compared to controls
• mice spend less time in open arm during elevated zero maze test as compared to controls
• repetitive grooming
• impaired motor coordination in rotarod test

nervous system
• decreased pop spike amplitude in the dorsal striatum as compared to controls
• presynaptic function, as determined by relationship of stimulation intensity to negative peak amplitude, is similar to control


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory