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Phenotypes Associated with This Genotype
Genotype
MGI:5776354
Allelic
Composition
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm5.1Gfng mutation (1 available); any Shank3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decreased total distance travelled in open field test as compared to controls
• mice spend less time in open arm during elevated zero maze test as compared to controls
• repetitive grooming
• impaired motor coordination in rotarod test

nervous system
• decreased pop spike amplitude in the dorsal striatum as compared to controls
• presynaptic function, as determined by relationship of stimulation intensity to negative peak amplitude, is similar to control

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:229668


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory