Phenotypes Associated with This Genotype

Genotype
MGI:5774963

• Allelic Composition: Map1a^m1J/Map1a^m1J
• Genetic Background: C57BLKS/J-Map1a^m1J/SlacJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:220153 )

N • mice do not exhibit neuronal death or reactive gliosis in noncerebellar region

abnormal Purkinje cell morphology ( J:220153 )

• reduced microtubule network

Purkinje cell degeneration ( J:220153 )

• at 7 months in the cerebellar cortex and by 18 months in the cerebellum

• transgene expression of the LC2 isoform doesnt not rescue Purkinje cell degeneration

• however, no loss is observed prior to 3 months and transgene expression of the precursor gene rescues Purkinje cell loss

abnormal Purkinje cell dendrite morphology ( J:220153 )

• focal swellings beginning at 6 weeks and becoming more widespread with age

thin cerebellar molecular layer ( J:220153 )

• at 18 months of age

abnormal axon morphology ( J:220153 )

• axonal torpedos beginning at 6 weeks of age

abnormal axon initial segment morphology ( J:220153 )

• hypertrophic or exhibiting abnormal blebs at 2 months

• transgene expression of the LC2 isoform doesnt not rescue the axon initial segment phenotype

behavior/neurological

ataxia ( J:220153 )

• mild