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Phenotypes Associated with This Genotype
Genotype
MGI:5766948
Allelic
Composition
Del(16Dgcr2-Hira)3Aam/+
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduction in dendritic complexity in primary cultured neurons, with hippocampal neurons exhibiting a 38% decrease in the number of primary dendrites, a 45% decrease in the number of branch points and a decrease in the total length of dendrites
• 8 week old mice show a decrease in the number of branch points in the basal dendritic tree of CA1 neurons
• reduction in the mushroom spine density in CA1 pyramidal neurons and in primary cultured neurons
• average spine head width is decreased by 23% and the average length is decreased by 18.5% in primary cultured neurons
• CA1 pyramidal neurons show a decrease in spine width but not spine length
• reduction in the density of glutamatergic synapses in vitro and in vivo
• miniature excitatory postsynaptic currents (MEPSCs) occur at lower frequencies in primary cultured hippocampal neurons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
DiGeorge syndrome DOID:11198 OMIM:188400
J:141432


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory