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Phenotypes Associated with This Genotype
involves: 129S7/SvEvBrd
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phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduction in dendritic complexity in primary cultured neurons, with hippocampal neurons exhibiting a 38% decrease in the number of primary dendrites, a 45% decrease in the number of branch points and a decrease in the total length of dendrites
• 8 week old mice show a decrease in the number of branch points in the basal dendritic tree of CA1 neurons
• reduction in the mushroom spine density in CA1 pyramidal neurons and in primary cultured neurons
• average spine head width is decreased by 23% and the average length is decreased by 18.5% in primary cultured neurons
• CA1 pyramidal neurons show a decrease in spine width but not spine length
• reduction in the density of glutamatergic synapses in vitro and in vivo
• miniature excitatory postsynaptic currents (MEPSCs) occur at lower frequencies in primary cultured hippocampal neurons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
DiGeorge syndrome DOID:11198 OMIM:188400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory