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Phenotypes Associated with This Genotype
Genotype
MGI:5762620
Allelic
Composition
Tg(S100b-v-erbB)4496Waw/0
Trp53tm1Brd/Trp53tm1Brd
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(S100b-v-erbB)4496Waw mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (210 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• marker analysis indicates that oligodendroglial progenitor cell-derived high grade glioma has proneural character
• in vivo radiation of the high grade glioma induces proneural-to-mesenchymal transition, increasing invasiveness and malignancy
• irradiated proneural high grade glioma cells undergoing proneural-to-mesenchymal transition show increased invasiveness and resistance to temozolomide treatment

nervous system
• marker analysis indicates that oligodendroglial progenitor cell-derived high grade glioma has proneural character
• in vivo radiation of the high grade glioma induces proneural-to-mesenchymal transition, increasing invasiveness and malignancy
• irradiated proneural high grade glioma cells undergoing proneural-to-mesenchymal transition show increased invasiveness and resistance to temozolomide treatment

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
high grade glioma DOID:3070 OMIM:PS137800
J:137800


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory