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Phenotypes Associated with This Genotype
Genotype
MGI:5753081
Allelic
Composition
Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aspmtm1(cre)Mrc mutation (0 available); any Aspm mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• neural progenitor cells exhibit elongated cell cycle length, with a delay in progression through S- and G2/M-phases and significant lengthening of the G1 only in late (E16.5) cells
• the transition through the G1-R point is postponed

growth/size/body
• fully penetrant 20% smaller wet brain weight as embryos and continuing throughout life, particularly a reduction in cortical dimension

nervous system
• extended corticogenesis
• neural progenitor cells carry out more P-N asymmetric-neurogenic divisions in young E12.5 embryos and more N-N symmetric-neurogenic divisions in older E14.5 embryos, always at the expense of P-P symmetric-proliferative divisions
• cortices at E18.5 show delayed astrogenesis
• 20% smaller wet brain weight
• adults show thinning of the cortex stemming from a reduction of the superficial, later born layers II-IV and a corresponding increase in older and deeper layer VI cells
• cortices at E18.5 show delayed astrogenesis
• astrocyte progenitors, RC2+ radial glia cells, show disturbed fiber alignment and fewer immature GFAP+ astrocytes are seen
• progressive reduction of neural progenitor cell compartment at mid-to-late corticogenesis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microcephaly DOID:10907 OMIM:251200
OMIM:604321
OMIM:604804
OMIM:608393
OMIM:608716
OMIM:612703
J:228026


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory