About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5752905
Allelic
Composition
Kif1algdg/Kif1algdg
Genetic
Background
C3.Cg-Kif1algdg/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif1algdg mutation (1 available); any Kif1a mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• of 743 pups born from heterozygous intercrosses 139 were mutant, 6 were born dead, 2 were found dead after birth, and 12 were missing before wean age, which is a yield of approximately 21% assuming all dead and missing were mutant, less than the 25% expected

hearing/vestibular/ear
• one homozygote assessed at 18 days of age was found to have severe hearing loss

behavior/neurological
• wWhen raised by their tails they do not splay their legs outward and some cross the front pair and the rear pair
• a few homozygotes nearing wean age are found to roll over and over in a struggle to right themselves
• progressive paralysis can first present as early as 2 weeks of age and is eveident by 3 weeks of age, homozygotes lose most of the use of their rear legs such that they drag their rear legs and pull themselves along with their front legs to move

growth/size/body
• homozygotes are slightly smaller than littermate controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary spastic paraplegia 30 DOID:0110781 OMIM:610357
J:229662


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/09/2019
MGI 6.14
The Jackson Laboratory