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Phenotypes Associated with This Genotype
Genotype
MGI:5752860
Allelic
Composition
Cul3tm1.1Arte/Cul3+
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul3tm1.1Arte mutation (0 available); any Cul3 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice under general anesthesia exhibit higher blood pressure
• the systolic aortic pressure wave is augmented while the diastolic relaxation is slowed, suggesting early wave reflection of the pressure wave and compliance changes indicating vascular stiffness
• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice

growth/size/body

homeostasis/metabolism
• mice exhibit hyperchloremia
• pH is maintained by an increased respiratory drive to increase CO2 removal and hence reduced total CO2 and pCO2 levels
• compensated metabolic acidosis

muscle
• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory