cardiovascular system
hypertension
(
J:229424
)
• mice under general anesthesia exhibit higher blood pressure
|
• the systolic aortic pressure wave is augmented while the diastolic relaxation is slowed, suggesting early wave reflection of the pressure wave and compliance changes indicating vascular stiffness
|
• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice
|
growth/size/body
homeostasis/metabolism
hyperkalemia
(
J:229424
)
• mice exhibit hyperchloremia
|
• pH is maintained by an increased respiratory drive to increase CO2 removal and hence reduced total CO2 and pCO2 levels
|
• compensated metabolic acidosis
|
muscle
• maximal constrictor response to intravenous administration of phenylephrine and angiotensin II are higher than in wild-type mice
|