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Phenotypes Associated with This Genotype
Genotype
MGI:5752255
Allelic
Composition
Eif2b5tm1Itl/Eif2b5tm1Itl
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2b5tm1Itl mutation (0 available); any Eif2b5 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• primary microglial cells exhibit impaired production of cytokines in response to LPS

immune system
• primary microglial cells exhibit impaired production of cytokines in response to LPS

nervous system
• primary microglial cells exhibit impaired production of cytokines in response to LPS
• astrocyte cultures treated with LPS show abnormal morphology, remaining flat shaped rather than star shape in response to activation
• mice exhibit impaired astrogliosis in response to systemic stress induced by lipopolysaccharide (LPS)
• primary astrocytes exhibit impaired production of cytokines in response to LPS

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
leukoencephalopathy with vanishing white matter DOID:0060868 OMIM:603896
J:192103


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory