Analysis Tools
behavior/neurological
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• mice exhibit impaired contextual long-term memory at 6 weeks of age
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• mice make more entries into, travel greater distances, and spend increased time in the open arm of the elevated plus maze at 6 weeks of age, indicating decreased anxiety
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• mice exhibit increased footslips when walking on an array of parallel bars, decreased ability to remain suspended on a 1/4 inch diameter dowel, and impaired ability to learn the accelerating rotating rod walking task at 6 weeks of age
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cardiovascular system
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• mice over 8 weeks of age show increased incidence of arrhythmia
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• mice over 8 weeks of age show increased corrected QT interval time
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growth/size/body
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• mice are underweight at weaning but recover to wild-type body weight by 6 weeks of age
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mortality/aging
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• median survival of 61 days
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nervous system
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• mice exhibit decreased evoked field excitatory post-synaptic potential (fEPSP) slope in CA1 region of the hippocampus
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• mice exhibit decreased evoked field excitatory post-synaptic potential (fEPSP) slope in CA1 region of the hippocampus, indicating impaired long-term potentiation
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respiratory system
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• 6-8 week old mice have increased breathing rate at baseline and when exposed to a hypoxic gas challenge
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Rett syndrome | DOID:1206 |
OMIM:312750 OMIM:613454 |
J:220859 | |
