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Phenotypes Associated with This Genotype
Genotype
MGI:5751707
Allelic
Composition
Mecp2tm1.1Irsf/Y
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Irsf mutation (1 available); any Mecp2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit impaired contextual long-term memory at 6 weeks of age
• mice make more entries into, travel greater distances, and spend increased time in the open arm of the elevated plus maze at 6 weeks of age, indicating decreased anxiety
• mice exhibit increased footslips when walking on an array of parallel bars, decreased ability to remain suspended on a 1/4 inch diameter dowel, and impaired ability to learn the accelerating rotating rod walking task at 6 weeks of age

cardiovascular system
• mice over 8 weeks of age show increased incidence of arrhythmia
• mice over 8 weeks of age show increased corrected QT interval time

growth/size/body
• mice are underweight at weaning but recover to wild-type body weight by 6 weeks of age

mortality/aging
• median survival of 61 days

nervous system
• mice exhibit decreased evoked field excitatory post-synaptic potential (fEPSP) slope in CA1 region of the hippocampus
• mice exhibit decreased evoked field excitatory post-synaptic potential (fEPSP) slope in CA1 region of the hippocampus, indicating impaired long-term potentiation

respiratory system
• 6-8 week old mice have increased breathing rate at baseline and when exposed to a hypoxic gas challenge

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:220859


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory