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Phenotypes Associated with This Genotype
Genotype
MGI:5751684
Allelic
Composition
Tg(Trp53)1Srn/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Trp53)1Srn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 17% of mice exhibit tumors following spontaneous death as compared to 47% of wild-type mice
• mice develop fewer 3MC-induced fibrosarcomas as compared to wild-type; 8/12 mice are tumor free, 11/12 wild-type mice develop fibrosarcomas
• mice develop fewer BBN-induced urinary bladder carcinomas as compared to wild-type; tumors that develop are monofocal rather than multifiocal and develop later

immune system
• increased induction of apoptosis in thymus following whole body irradiation

mortality/aging
N
• survival at 2 years of age is similar to wild-type (respectively 70% and 78%)
• mice exhibit signs of aging (hair growth, lordokyphosis, skin thickness and osteoporosis) similar to wild-type
• Mendelian ratios from a hemizygote x wild type matings are as predicted

endocrine/exocrine glands
• increased induction of apoptosis in thymus following whole body irradiation

cellular
• increased induction of apoptosis in thymus following whole body irradiation

hematopoietic system
• increased induction of apoptosis in thymus following whole body irradiation

reproductive system
N
• hemizygote x wild type matings produce litters sizes similar to wild-type

homeostasis/metabolism
• mice develop fewer 3MC-induced fibrosarcomas as compared to wild-type; 8/12 mice are tumor free, 11/12 wild-type mice develop fibrosarcomas
• mice develop fewer BBN-induced urinary bladder carcinomas as compared to wild-type; tumors that develop are monofocal rather than multifiocal and develop later


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory