Phenotypes for Shh Vps25 MGI:5751502 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Shh^tm1Chg/Shh⁺ Vps25^m1Lis/Vps25^m1Lis
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm1Chg mutation (2 available); any Shh mutation (48 available)
Vps25^m1Lis mutation (0 available); any Vps25 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

mandible hypoplasia ( J:223082 )

• as in Vps25^m1Lis homozygotes

short snout ( J:223082 )

• stunted as in Vps25^m1Lis homozygotes

abnormal outer ear morphology ( J:223082 )

• as in Vps25^m1Lis homozygotes

growth/size/body

mandible hypoplasia ( J:223082 )

• as in Vps25^m1Lis homozygotes

short snout ( J:223082 )

• stunted as in Vps25^m1Lis homozygotes

abnormal outer ear morphology ( J:223082 )

• as in Vps25^m1Lis homozygotes

limbs/digits/tail

polydactyly ( J:223082 )

• partial rescue of polydactyly observed in Vps25^m1Lis homozygotes

skeleton

mandible hypoplasia ( J:223082 )

• as in Vps25^m1Lis homozygotes

hearing/vestibular/ear

abnormal outer ear morphology ( J:223082 )

• as in Vps25^m1Lis homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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