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Phenotypes Associated with This Genotype
Genotype
MGI:5751210
Allelic
Composition
C9orf72em5Lutzy/C9orf72em5Lutzy
Genetic
Background
C57BL/6-C9orf72em5Lutzy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C9orf72em5Lutzy mutation (1 available); any C9orf72 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice exhibit no abnormalities in sensorimotor coordination, limb strength, and muscle electrophysiology

cellular

hematopoietic system
• altered immune responses in macrophages
• altered immune responses in microglia

immune system
• altered immune responses in macrophages
• altered immune responses in microglia
• with accumulation of engorged macrophage-like cells

nervous system
N
• mice exhibit no evidence of motor neuron disease or histological neurodegeneration through advanced age (17 months)
• mice exhibit no abnormalities in femoral motor and sensory axon counts
• altered immune responses in microglia
• chromatolytic structures are observed in gray and white matter of the spinal cord
• chromatolytic structures are observed in gray and white matter of the spinal cord


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory