Phenotypes Associated with This Genotype

Genotype
MGI:5707901

• Allelic Composition: Rps27l^{Gt(IST11658B7)Tigm}/Rps27l^{Gt(IST11658B7)Tigm}; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:223276 )

• 7 of 14 mice develop T-lymphoblastic lymphoma

• 1 of 14 mice develop T-cell lymphoma in thymus, lymph node and spleen

mortality/aging

mortality/aging ( J:223276 )

N • postnatal lethality observed in Rps27l^{Gt(IST11658B7)Tigm} homozygotes is rescued

premature death ( J:223276 )

• mice die sooner than mice with a wild-type allele of Rps271

neoplasm

increased T cell derived lymphoma incidence ( J:223276 )

• 7 of 14 mice develop T-lymphoblastic lymphoma

• 1 of 14 mice develop T-cell lymphoma in thymus, lymph node and spleen

increased B cell derived lymphoma incidence ( J:223276 )

• in 1 of 14 mice

hematopoietic system

enlarged spleen ( J:223276 )

decreased bone marrow cell number ( J:223276 )

• partially rescued

cellular

aneuploidy ( J:223276 )

• in lymphoma cells and mouse embryonic fibroblasts

chromosomal instability ( J:223276 )

growth/size/body

growth/size/body region phenotype ( J:223276 )

N • growth retardation and organ hypocellularity (spleen, thymus and bone marrow) observed in Rps27l^{Gt(IST11658B7)Tigm} homozygotes is rescued

enlarged liver ( J:223276 )

enlarged spleen ( J:223276 )

immune system

enlarged spleen ( J:223276 )

enlarged lymph nodes ( J:223276 )

• in 1 of 14 mice

liver/biliary system

enlarged liver ( J:223276 )