Phenotypes for Dmrtb1 MGI:5707840 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmrtb1^tm1.1Zark/Dmrtb1^tm1.1Zark
Genetic Background	involves: 129S1/Sv

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmrtb1^tm1.1Zark mutation (0 available); any Dmrtb1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:217504 )

N	• Background Sensitivity: minimal loss of spermatogonia

abnormal male meiosis ( J:217504 )

• more cells entering meiosis

arrest of male meiosis ( J:217504 )

• meiosis arrested in prophase

• spermatocytes do not progress past pachynema

abnormal synaptonemal complex ( J:217504 )

• formation of complex begins but often fails to be completed in males

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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