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Phenotypes Associated with This Genotype
Genotype
MGI:5703732
Allelic
Composition
Tg(Prnp-MAPT*R406W)21807Dwst/?
Genetic
Background
FVB/N-Tg(Prnp-MAPT*R406W)21807Dwst
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• prominent microgliosis in the neocortex, amygdala, and hippocampus
• occasional cell bodies and processes of the pyramidal cells of the hippocampus and amygdala of 14 month old mice show Gallyas-Braak staining, indicating neurofibrillary tangles
• tau accumulation beginning in the hippocampus and amygdala at 6 months of age, with progressive spreading to the cortices and subcortical areas
• tau localizes predominately in the cell bodies and processes of the neocortical neurons and accumulates in the cell bodies and dendrites of neurons in the anterior horn of the spinal cord and in neuronal processes in the neocortex
• cell bodies of piriform cortex neurons and neurons in the amygdala show massive (15- to 30-nm) straight filaments
• however, no amyloid beta deposition is seen
• astrogliosis is seen in the neocortex, amygdala, and hippocampus at 10 months of age

behavior/neurological
• 10 month old mice are able to learn to avoid electrical stimuli in the dark compartment within 5 serial trials in 1 week, however the retention time for the avoidance reaction begins to decrease 7 weeks later and worsens over time compared to control mice
• mice show a decrease in retention time on the rotating rod at 10 and 12 months, but not at 5 months, of age

hematopoietic system
• prominent microgliosis in the neocortex, amygdala, and hippocampus

immune system
• prominent microgliosis in the neocortex, amygdala, and hippocampus

muscle
N
• no atrophy of skeletal muscle is seen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274
J:95971


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory