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Phenotypes Associated with This Genotype
Genotype
MGI:5700345
Allelic
Composition
Tg(Plp1-HTT*150Q)4aXjl/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice start to die at 5 months of age and do not survive past 10 months

growth/size/body
• body weight begins to decrease at 4 months of age and continues to decrease progressively

behavior/neurological
• mice show increased sensitivity to flurothyl-induced seizures
• 5 month old mice exhibit difficulty walking
• 5 month old mice exhibit clasping
• 5 month old mice exhibit tremors
• progressive motor dysfunction on the rotarod with age
• locomotor activity is lower during active times (7 pm to 11 pm)

nervous system
• mice show increased sensitivity to flurothyl-induced seizures
• degenerated axons, appearing swollen and dark, are seen at 5 months of age, but not at 3 months
• reduction of myelination in striatum axons is seen at 3 months but not earlier and becomes more severe at 5 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:221608


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory