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Phenotypes Associated with This Genotype
Genotype
MGI:5699329
Allelic
Composition
Tg(SOD1*H46R)IAra/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1*H46R)IAra mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• rotarod scores start to decrease at 18 weeks of age
• mice develop motor paralysis starting from the hindlimbs, spreading to the rest of the body; disease onset is on average 146 and 157 days in males and females, respectively
• duration of disease is on average 31 and 25 days in males and females, respectively

growth/size/body
• mice begin to lose weight from 16 weeks of age

mortality/aging
• shorter lifespan, with average lifespan of 177 and 182 days in males and females, respectively

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 1 DOID:0060193 OMIM:105400
J:221350


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory