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Phenotypes Associated with This Genotype
Genotype
MGI:5698610
Allelic
Composition
Olig1tm1(cre)Rth/Olig1tm1(cre)Rth
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig1tm1(cre)Rth mutation (1 available); any Olig1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• cortical volume like controls
• no significant increase in inhibitory activity on pyramidal cells
• 35% increase in interneuron precursor cells expressing parvalbumin and calretinin but not neuropeptide-Y or somatostatin
• 30% increase in cells expressing GABA and GAD67
• increase in parvalbumin interneuron synapse on cortical pyramidal neurons
• increased interneuron production in the olfactory bulb
• increased interneuron production
• in the corpus callosum, motor cortex, and cerebellar white matter at 21 and 50 days of age
• also reduced in the ventral telencephalon where there is a 30% increase of interneurons


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory