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Phenotypes Associated with This Genotype
Genotype
MGI:5696188
Allelic
Composition
Col4a4bwk/Col4a4bwk
Genetic
Background
NON;NZO-Col4a4bwk/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col4a4bwk mutation (3 available); any Col4a4 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean age of death is 124 days
• Background Sensitivity: lifespan is longer than in DBA/2J background

renal/urinary system
• progressive elevated ACR (albumin to creatinine ratio) beginning at 4 weeks of age
• Background Sensitivity: ratios are highest in mice on the DBA/2J background as compared to the 129S1 and NON;NZO backgrounds
• diffuse infiltrates of inflammatory cells observed in kidneys at 3 months of age
• tubulointerstitial nephritis
• fibrocellular crescents observed in some glomeruli at 3 months of age
• synechiae observed in some glomeruli at 3 months of age
• expanded interstitium
• mesangial matrix replaces or encroaches on many tubules by 3 months of age
• tubular atrophy observed at 3 months of age
• dilated tubules at 3 months of age
• tubular protein casts

vision/eye
N
• no eye pathology is detected

immune system
• diffuse infiltrates of inflammatory cells observed in kidneys at 3 months of age
• tubulointerstitial nephritis

hearing/vestibular/ear
N
• no hearing pathology is detected

homeostasis/metabolism
• progressive elevated ACR (albumin to creatinine ratio) beginning at 4 weeks of age
• Background Sensitivity: ratios are highest in mice on the DBA/2J background as compared to the 129S1 and NON;NZO backgrounds

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive Alport syndrome DOID:0110033 OMIM:203780
J:223185


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/09/2022
MGI 6.21
The Jackson Laboratory