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Phenotypes Associated with This Genotype
Genotype
MGI:5695364
Allelic
Composition
Srsf2tm1.1Oaw/Srsf2+
Tg(Mx1-cre)1Cgn/?
Genetic
Background
B6.Cg-Tg(Mx1-cre)1Cgn Srsf2tm1.1Oaw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srsf2tm1.1Oaw mutation (1 available); any Srsf2 mutation (2 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• percentage of LSK cells is decreased in G1 and increased in S as compared to controls
• increase in the proportion of apoptotic hematopoietic stem (LSK) cells

hematopoietic system
• erythroid dysplasia
• decrease in intermediate myeloid progenitors (pre-MEGE, pre-CFUE)
• myeloid dysplasia
• appearance of nuclear irregularities and cytoplasmic vacuolization and blebbing of erythroid precursors
• appearance of hypolobated and hypogranulated neutrophils
• decreased numbers of B cells in peripheral blood at all stages beginning at pro-B cell number
• increase in splenic LSK cells 14 weeks after pIpC injection although splenomegaly is not observed
• leukopenia is observed in bone marrow of lethally irradiated recipient mice 18 weeks post-transplantation (pIpC injection 4 weeks after transplantation)
• anemia is observed 18 weeks post-bone marrow transplantation (pIpC injection 4 weeks after transplantation)
• mean corpuscular volume (MCV) is increased in donor bone marrow post-transplantation
• hemoglobin is decreased in donor bone marrow post-transplantation
• increase in total hematopoietic stem cell (LSK) cell number in non-competitive bone marrow transplantation assay 14 weeks after pIpC injection relative to controls
• increase in restricted hematopoietic progenitor cells (LSK, CD48+, CD150+) in bone marrow transplantation assay 14 weeks after pIpC injection relative to controls increase in restricted hematopoietic progenitor cells (LSK, CD48+, CD150+) in bone marrow transplantation assay 14 weeks after pIpC injection relative to controls increase in restricted hematopoietic progenitor cells (LSK, CD48+, CD150+) in bone marrow transplantation assay 14 weeks after pIpC injection relative to controls
• increase in total LSK cell number in bone marrow in competitive bone marrow transplantation assay 14 weeks post-pIpC injection
• increase in proportion of apoptotic hematopoietic stem (LSK) cells
• percentage of LSK cells is decreased in G1 and increased in S as compared to controls

immune system
• decrease in intermediate myeloid progenitors (pre-MEGE, pre-CFUE)
• myeloid dysplasia
• appearance of hypolobated and hypogranulated neutrophils
• decreased numbers of B cells in peripheral blood at all stages beginning at pro-B cell number

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myelodysplastic syndrome DOID:0050908 OMIM:614286
J:221404


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory