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Phenotypes Associated with This Genotype
Genotype
MGI:5694491
Allelic
Composition
Lrp6tm1Arma/Lrp6tm1Arma
Genetic
Background
C57BL/6-Lrp6tm1Arma
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp6tm1Arma mutation (0 available); any Lrp6 mutation (58 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice on a high-cholesterol diet for 6 months exhibit gross enlargement of the liver

homeostasis/metabolism
• mice on a high-cholesterol diet for 6 months exhibit elevated plasma levels of bilirubin
• mice on a high-cholesterol diet for 6 months exhibit elevated plasma levels of aspartate aminotransferase
• mice exhibit impaired response to intraperitoneal insulin administration
• however, mice have normal baseline insulin and glucose levels
• mice on a high-cholesterol diet for 6 months exhibit greater neutral lipid storage in primary hepatocytes than wild-type hepatocytes
• mice fed a chow diet show increased hepatic triglyceride and VLDL particle synthesis and secretion
• mice on a high-cholesterol diet exhibit an increase in de novo lipogenesis
• however, mice show normal VLDL clearance
• mice on a high-cholesterol diet for 6 months show a 2-fold increase in plasma triglyceride levels, with a higher triglyceride in the VLDL fraction and higher cholesterol in the non-HDL cholesterol fraction
• the increase in triglyceride levels is predominantly associated with VLDL particles
• mice on a high-cholesterol diet for 6 months show higher triglyceride in the VLDL fraction
• chow fed mice show increased total cholesterol levels
• mice exhibit an increase in non-HDL cholesterol (IDL/LDL)
• mice on a high-cholesterol diet for 6 months show a 3-fold increase in total cholesterol levels compared to wild-type mice on the same diet
• chow fed mice show increased LDL cholesterol
• mice on a high-cholesterol diet for 6 months show a 3-fold increase in total cholesterol levels and LDL cholesterol
• mice on a high-cholesterol diet for 6 months exhibit higher hepatic cholesterol ester content (J:210538)
• mice fed a high cholesterol diet for 7 months show a greater hepatic fat content than wild-type mice (J:225450)
• mice show greater 18:1n9 fatty acid content when fed a high-cholesterol diet compared to wild-type mice
• mice on a high-cholesterol diet for 6 months exhibit higher total hepatic triglyceride content

immune system
• mice on a chow diet exhibit infiltration of the liver with inflammatory cells at 9 months of age
• mice fed a high cholesterol diet for 7 months exhibit considerable infiltration of inflammatory cells into the liver that is not seen in wild-type mice fed the same diet

liver/biliary system
• mice on a chow diet exhibit infiltration of the liver with inflammatory cells at 9 months of age
• mice fed a high cholesterol diet for 7 months exhibit considerable infiltration of inflammatory cells into the liver that is not seen in wild-type mice fed the same diet
• mice fed a high cholesterol diet exhibit altered hepatic tissues surrounding portal and central veins
• mice on a high-cholesterol diet for 6 months exhibit gross enlargement of the liver
• mice on a high-cholesterol diet for 6 months exhibit higher hepatic cholesterol ester content (J:210538)
• mice fed a high cholesterol diet for 7 months show a greater hepatic fat content than wild-type mice (J:225450)
• mice on a high-cholesterol diet for 6 months exhibit higher total hepatic triglyceride content
• mice on a high-cholesterol diet for 6 months develop fatty liver with higher fat content than in wild-type mice (J:210538)
• mice fed a high cholesterol diet for 7 months show a greater hepatic fat content than wild-type mice indicating development of hepatosteatosis (J:225450)
• mice fed a high cholesterol diet for 7 months develop liver fibrosis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
fatty liver disease DOID:9452 OMIM:228100
J:225450


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory