Phenotypes Associated with This Genotype

Genotype
MGI:5694193

• Allelic Composition: Aldob^{tm1(KOMP)Vlcg}/Aldob^{tm1(KOMP)Vlcg}
• Genetic Background: C57BL/6NTac-Aldob^{tm1(KOMP)Vlcg}
• Cell Lines: 15350B-F10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:220330 )

• when fed regular chow and 40% fructose solution, homozygotes show a severe mortality rate and die within 3 days, unlike control littermates

• when fed fructose-free chow and water, homozygotes display normal survival

growth/size/body

decreased body size ( J:220330 )

• when exposed to low levels of fructose prior to weaning, homozygotes tend to be smaller than control littermates at weaning

• after weaning, if fed a fructose-free chow, homozygotes reach the same size as control littermates within two weeks

liver/biliary system

liver inflammation ( J:220330 )

• mutant livers show an increase in inflammatory cells within the first day of exposure to a 40% fructose solution

abnormal liver morphology ( J:220330 )

• homozygotes that expire due to fructose ingestion exhibit abnormal liver gross anatomy and a firmer liver texture

• on a high fructose diet, mutant livers show significant damage and tissue tearing

abnormal portal triad morphology ( J:220330 )

• mutant livers display altered morphology of the portal triad within the first day of exposure to a 40% fructose solution

hepatic steatosis ( J:220330 )

• mutant livers show increased lipid deposits relative to wild-type controls, even with little (40%) or no fructose in the diet for 21 days

liver fibrosis ( J:220330 )

• mutant livers exhibit stress fibers within the first day of exposure to a 40% fructose solution

pale liver ( J:220330 )

• homozygotes that expire following fructose ingestion show clearly discolored livers

immune system

liver inflammation ( J:220330 )

• mutant livers show an increase in inflammatory cells within the first day of exposure to a 40% fructose solution