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Phenotypes Associated with This Genotype
Genotype
MGI:5689841
Allelic
Composition
Tg(Thy1-TARDBP*)BOddo/Tg(Thy1-TARDBP*)BOddo
Genetic
Background
C57BL/6-Tg(Thy1-TARDBP*)BOddo
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• 15 month old mice perform worse than wild-type mice on the Morris water maze on day 2-5, traveling longer distances to find the hidden platform, showing fewer platform location crosses and spending less time in the target quadrant
• 15 month old homozygotes perform worse than wild-type or hemizygotes in the radial arm water maze showing more entries in arms without platform on day 2, indicating impaired spatial memory
• 15 month old mutants show fewer number of re-entries in the same arm of the radial arm water maze during each single trial, indicating impaired working memory
• 15 month old homozygotes perform worse than wild-type controls or hemizygotes on the rotarod and on the accelerated rotarod

cellular
• marker analysis indicates that autophagy induction is reduced in 15 month old mutants

homeostasis/metabolism
• marker analysis indicates that autophagy induction is reduced in 15 month old mutants
• 15 month old homozygotes show a decrease in chymotrypsin-like, trypsin-like, and caspase-like activities of the proteasome in the brain, indicating a decrease in proteasome function

nervous system
• mice show increased soluble levels of the 25 kDa C-terminal fragment of TARDBP in the nucleus and cytosol
• mice show rare cytosolic TARDBP (TDP-43) deposits


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory