Phenotypes Associated with This Genotype

Genotype
MGI:5689331

• Allelic Composition: Dtnbp1^sdy/Dtnbp1^sdy
• Genetic Background: B6J.D2-Dtnbp1^sdy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal operant conditioning behavior ( J:197066 )

♂ • mice exhibit normal performance in a reward-based operant task during habituation but require more days and trials to reach criterion in the testing phase, indicating delayed learning

♂ • despite requiring more time to reach criterion, mice respond faster on correct trails compared to wild-type mice and there are no differences in response to latency on incorrect trials or latency to retrieve reward pellets

♂ • mutants produce more responses and fewer omissions than wild-type mice on day 1 of testing due to increased compulsive and impulsive responses

♂ • over the course of testing (7 days), mutants decrease impulsive and compulsive responses and when they reach criterion, their impulsive and compulsive response totals are no different from wild-type mice

decreased anxiety-related response ( J:223954 )

♂ • in the elevated plus maze, mutants are more resistant to anxiety-promoting effects of constant light than wild-type mice; lighting conditions do not affect behavior of mutants in the elevated plus maze like they do for wild-type mice which spend less time in the open arms after the constant light condition

increased locomotor activity ( J:223954 )

♂ • mutants show comparable locomotor activity in the initial light-dark condition, but show an increase in total locomotor activity following exposure to constant light conditions, then a decrease in activity when exposed to the second light-dark condition that is still higher than seen in wild-type mice

abnormal circadian behavior ( J:223954 )

♂ • circadian rhythms are mainly normal under light-dark conditions or in constant darkness, however mice show longer free-running period under constant light and the subjective day/subjective night activity ratio is almost 3-times higher than in wild-type mice

♂ • the cycle-to-cycle variability of activity onsets during 12 hour-light:12 hour-dark (light-dark) condition, constant light, or constant darkness is higher than in wild-type mice, indicating that precision of locomotor activity rhythms are enhanced; variability is most pronounced during constant light, indicating that circadian clock is more sensitive to the effects of constant light

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:223954 )

♂N • corticosterone secretion in feces under both light-dark conditions and constant light conditions is similar to wild-type

nervous system

decreased prepulse inhibition ( J:223954 )

♂ • mice exhibit a deficit in prepulse inhibition under constant light conditions which is sustained even after mice are put in normal light-dark conditions; a light-dark exposure of 3 weeks after constant light partially reverses the prepulse inhibition deficits, however, it is still decreased compared to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:197066 , J:223954