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Phenotypes Associated with This Genotype
Genotype
MGI:5688660
Allelic
Composition
Lrit3tm1Lex/Lrit3tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrit3tm1Lex mutation (1 available); any Lrit3 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• Spectral-Domain Optical Coherence Tomography (SD-OCT) revealed that the thickness of a complex comprising inner plexiform layer, ganglion cell layer, and nerve fiber layer (IPL+GCL+NFL) is significantly decreased both at 6 weeks and at 6 months of age relative to wild-type and heterozygous controls
• SD-OCT showed that INL thickness is significantly reduced both at 6 weeks and at 6 months of age relative to wild-type and heterozygous controls
• in contrast, no statistical differences are observed in outer nuclear layer (ONL) thickness at 6 months
• under photopic conditions, homozygotes display increased a wave implicit times with increasing flash intensity
• under photopic conditions, homozygotes display increased b wave implicit times with increasing flash intensity
• under photopic conditions, homozygotes display larger a-wave amplitudes
• under photopic conditions, homozygotes display shorter b-wave amplitudes
• under photopic conditions, 6-wk-old homozygotes show highly variable ERG responses with larger a-wave amplitudes, shorter b-wave amplitudes, and longer implicit times of both waves relative to wild-type controls
• similar ERG responses are noted at 6 months of age
• under scotopic conditions, homozygotes exhibit no b-wave on their ERG responses, while a-waves are comparable in amplitude or implicit time to those in wild-type or heterozygous controls
• absence of the scotopic b-wave is noted at both 6 weeks and at 6 months of age, indicating that the phenotype is stationary
• under scotopic conditions, optomotor responses (number of head movements per min) are significantly reduced at all spatial frequencies and at both ages
• homozygotes exhibit visual dysfunction that affects both rod- and cone- ON-bipolar systems
• no obvious fundus autofluorescence abnormalities are observed

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital stationary night blindness 1F DOID:0110864 OMIM:615058
J:214644


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory