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Phenotypes Associated with This Genotype
Genotype
MGI:5661879
Allelic
Composition		 Comttm1(COMT)Xzho/Comttm1(COMT)Xzho
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Comttm1(COMT)Xzho mutation (2 available); any Comt mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:224284 )
N
• male mice exhibit normal exploratory behavior
enhanced contextual conditioning behavior ( J:224284 )
• female mice exhibit increased freezing for the first 6 minutes of the test and then a decline unlike Comttm2(COMT)Xzho homozygotes
impaired cued conditioning behavior ( J:224284 )
• female mice exhibit decreased cued fear recall compared with Comttm2(COMT)Xzho homozygotes
abnormal spatial working memory ( J:224284 )
• male and female mice exhibit reduced alternation compared with chance
• tolcapone treatment increases alteration unlike Comttm2(COMT)Xzho homozygotes
increased startle reflex ( J:224284 )
• in male mice compared with male Comttm2(COMT)Xzho homozygotes
decreased vertical activity ( J:224284 )
• in female mice compared with female Comttm2(COMT)Xzho homozygotes

nervous system
decreased prepulse inhibition ( J:224284 )
• in male mice compared with male Comttm2(COMT)Xzho homozygotes
increased prepulse inhibition ( J:224284 )
• in female mice compared with female Comttm2(COMT)Xzho homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory