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Phenotypes Associated with This Genotype
Genotype
MGI:5660857
Allelic
Composition
Nlgn3tm2.1Sud/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm2.1Sud mutation (1 available); any Nlgn3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit increased learning rate but similar initial coordination on the accelerating rotarod
• mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes, however no changes in movement velocity or in crossings through the center of the open field are seen
• mice exhibit greater number of wall jumps
• mice show an abnormal bias in the direction of rotation during locomotion
• mice perform similarly to wild-type littermates on the first trial of an accelerating rotarod, however in the last several trials, mice exhibit enhanced performance, with increased time on the rotarod before falling off compared to wild-type mice, indicating enhanced formation of repetitive motor routine
• the time spend performing stereotypic movements is enhanced during spontaneous open-field activity
• mice show increased vigor of stereotypic movements, indicated by greater force variance during periods of low mobility

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:214636


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory