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Phenotypes Associated with This Genotype
Genotype
MGI:5660499
Allelic
Composition
Juptm1Ruiz/Jup+
Tg(Myh6-Jup*)1Ajm/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juptm1Ruiz mutation (1 available); any Jup mutation (126 available)
Tg(Myh6-Jup*)1Ajm mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice exhibit similar cardiovascular phenotypes as single Tg(Myh6-Jup*)1Ajm transgenic mice
• increase in fibroadipocytes in the heart
• reduced left ventricular fractional shortening
• increase in left ventricular end diastolic diameter, left ventricular end systolic diameter, and left ventricular mass

adipose tissue
• increase in fibroadipocytes in the heart

muscle
• reduced left ventricular fractional shortening

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
arrhythmogenic right ventricular dysplasia 12 DOID:0110083 OMIM:611528
J:192719


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory