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Phenotypes Associated with This Genotype
Genotype
MGI:5660497
Allelic
Composition
Tg(Myh6-Jup*)1Ajm/0
Genetic
Background
involves: FVB/N
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No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 10%, 20%, and 60% of mice die at 6, 12, and 24 weeks of age, respectively

cardiovascular system
• increase in number of adipocytes in the heart, with predominant distribution in the epicardium and patchy distribution in the myocardium
• the ventricular/body weight ratio is increased
• interstitial fibrosis is increased about 2-fold
• left ventricular fractional shortening is decreased
• left ventricular end diastolic diameter, end systolic diameter, left ventricular mass are increased
• electrocardiograms show evidence of supraventricular tachycardia in some mice
• electrocardiograms show evidence of ventricular arrhythmias
• electrocardiograms show evidence of third-degree atrioventricular block and atrioventricular dissociation in some mice

adipose tissue
• increase in number of adipocytes in the heart, with predominant distribution in the epicardium and patchy adipocyte distribution in the myocardium
• cardiac progenitor cells isolated from mutants exhibit enhanced adipogenesis

cellular
• cardiac progenitor cells isolated from mutants exhibit enhanced adipogenesis

muscle
• left ventricular fractional shortening is decreased

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
arrhythmogenic right ventricular dysplasia 12 DOID:0110083 OMIM:611528
J:192719


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory