About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5659866
Allelic
Composition
Pik3cbtm1.1Jdo/Pik3cbtm1.1Jdo
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3cbtm1.1Jdo mutation (1 available); any Pik3cb mutation (151 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• newborn mice are smaller than littermates
• adult mice are slightly (but significantly) smaller than wild-type mice
• mice lose less body weight following bleomycin treatment as compared to wild-type
• lung weight increases but less than that of wild-type mice following bleomycin treatment

homeostasis/metabolism
• all mice survive bleomycin treatment; 25% of wild-type mice die
• mice exhibit resistance to bleomycin-induced lung fibrosis as compared to wild-type
• mice lose less body weight following bleomycin treatment as compared to wild-type
• lung weight increases but less than that of wild-type mice following bleomycin treatment
• some mice have normal lungs, others show limited areas of fibrosis following bleomycin treatment

mortality/aging
• all mice survive bleomycin treatment; 25% of wild-type mice die
• heterozygote x heterozygote matings produce fewer homozygotes than expected

respiratory system
• lung weight increases but less than that of wild-type mice following bleomycin treatment
• some mice have normal lungs, others show limited areas of fibrosis following bleomycin treatment


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory