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Phenotypes Associated with This Genotype
Genotype
MGI:5659847
Allelic
Composition
Mto1Gt(G019A03)Wrst/Mto1Gt(G019A03)Wrst
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mto1Gt(G019A03)Wrst mutation (0 available); any Mto1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• marked arrhythmias occur especially during induction and reversal of anesthesia
• 8 week old mice exhibit reduced anxiety-related behavior in the modified Hole Board test, showing increased percentage of time spent on the board in the anxiogenic center of the test area and reduced percentage of time spent at the partition and in group contact with the cage mates
• 8 week old mice show increased object exploration in the modified Hole Board test
• acoustic startle response shows an altered curve, with 9 week old mice showing lower response at maximum dB
• lighter weight females show a trend to improved performance on an accelerating rotarod at 10 weeks of age but not in aged mice
• males show impaired performance in advancing trials of the accelerating rotarod at 10 weeks of age but not in aged mice
• grip strength measurements show a tendency towards more strength in mutants at 10 weeks of age but not in aged mice (16-20 months)
• 8 week old mice exhibit increased horizontal locomotor activity in the modified Hole Board test, showing increased total distance traveled, mean velocity, and object exploration

cardiovascular system
• 10 month old mice show focal signs of myofiber degeneration (atrophy and vacuolization) and fibrosis
• focal necrosis in cardiac muscle cells with intracristal swelling in mitochondria and dilated sarcoplasmic reticulum in young adult mice
• heart weight at 22 weeks of age is increased related to body weight and is seen as a trend at 10 months of age
• slightly dilated hearts with increased diastolic and systolic internal left ventricular diameters
• however, fractional shortening is normal indicating that left ventricular function is preserved and posterior wall and septum thickness are normal
• heart rate is consistently reduced at different ages and conditions; in awake mice at 4 and 10 months, and in anaesthetized mice at 4 and 15 months
• high incidence of arrhythmic events, with 16 of 19 mice showing arrhythmias, mainly atrioventricular blocks, but also premature ventricular beats or a higher degree of sinoatrial node blocks
• marked arrhythmias occur especially during induction and reversal of anesthesia
• mice sometimes show premature ventricular beats
• mice mainly show atrioventricular blocks
• QT interval is slightly, but significantly increased
• mice sometimes show a higher degree of sinoatrial blocks

cellular
• focal necrosis in cardiac muscle cells with intracristal swelling in mitochondria and dilated sarcoplasmic reticulum in young adult mice
• cardiac muscle cells of young mice exhibit mitochondria with intracristal swelling
• maximal respiration rate of isolated heart mitochondria normalized to total protein is reduced in mutants
• lower amounts of complex I protein is seen in heart mitochondria and a tendency towards reduced complex I activity

growth/size/body
• body weight at 10 weeks of age is reduced

homeostasis/metabolism
• mice exhibit increased lethality compared to controls after treatment with the herbicide paraquat
• mice exhibit increased sensitivity to the herbicide paraquat, showing increased lethality and decreased locomotor activity

mortality/aging
• mice exhibit increased lethality compared to controls after treatment with the herbicide paraquat

muscle
• 10 month old mice show focal signs of myofiber degeneration (atrophy and vacuolization) and fibrosis
• focal necrosis in cardiac muscle cells with intracristal swelling in mitochondria and dilated sarcoplasmic reticulum in young adult mice
• cardiac muscle cells of young mice exhibit dilated sarcoplasmic reticulum


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory