Phenotypes Associated with This Genotype

Genotype
MGI:5648426

• Allelic Composition: Tg(IghMyc)22Bri/0
• Genetic Background: involves: C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:214383 )

♂ • almost all mice die by 200 days of age

neoplasm

increased lymphoma incidence ( J:214383 )

♂

hematopoietic system

increased B cell apoptosis ( J:214383 )

♂ • in B lymphocytes compared to wild-type controls but reduced compared to mice carrying the transgene and homozygous for Prps2^{tm1a(KOMP)Wtsi}

immune system

increased B cell apoptosis ( J:214383 )

♂ • in B lymphocytes compared to wild-type controls but reduced compared to mice carrying the transgene and homozygous for Prps2^{tm1a(KOMP)Wtsi}

cellular

increased B cell apoptosis ( J:214383 )

♂ • in B lymphocytes compared to wild-type controls but reduced compared to mice carrying the transgene and homozygous for Prps2^{tm1a(KOMP)Wtsi}