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Phenotypes Associated with This Genotype
Genotype
MGI:5647920
Allelic
Composition
Tg(Tff3-Tmem207)1Tamo/0
Genetic
Background
C57BL/6-Tg(Tff3-Tmem207)1Tamo
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• about 14% of females and 13% of males at 6-12 months of age develop spontaneous intradermal tumors with features resembling those of various human cutaneous adnexal tumors with high incidence
• all tumors are in the subcutaneous axilla, inguinal region, or back
• almost all tumors exhibit partial differentiation into sweat gland units
• all tumors form intradermal masses that usually resemble human cylindroma or spiradenoma and which are characterized by mosaic-like tumor nests of basaloid cells
• some tumors partially exhibit apocrine, follicular, and sebaceous differentiation
• some tumors exhibit a partial trichoepithelioma morphology
• several tumors resemble human adenoid cystic carcinoma with tubular and cribriform patterns
• in the cutaneous adnexal tumors, adenoid cystic carcinoma-like malignant tumors and malignant tumors with features of salivary-duct type adenocarcinoma are seen

integument
• about 14% of females and 13% of males at 6-12 months of age develop spontaneous intradermal tumors with features resembling those of various human cutaneous adnexal tumors with high incidence
• all tumors are in the subcutaneous axilla, inguinal region, or back
• almost all tumors exhibit partial differentiation into sweat gland units
• all tumors form intradermal masses that usually resemble human cylindroma or spiradenoma and which are characterized by mosaic-like tumor nests of basaloid cells
• some tumors partially exhibit apocrine, follicular, and sebaceous differentiation
• some tumors exhibit a partial trichoepithelioma morphology

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epidermal appendage tumor DOID:2433 J:217436


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory