About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5645990
Allelic
Composition
Cdk4tm1.1Bbd/Cdk4tm1.1Bbd
Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic
Background
FVB.Cg-Cdk4tm1.1Bbd Tg(Tyr-NRAS*Q61K)1Bee
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1.1Bbd mutation (0 available); any Cdk4 mutation (30 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• spontaneous development of malignant melanoma by 300 days of age in all mice
• malignant melanomas have the appearance of nodular lesions and tumors show larger and more pleomorphic nuclei, abundant cytoplasm and numerous multinucleated giant cells and low levels of Ki-67 staining
• two distinct malignant melanoma subtypes are seen: 55% of melanomas are in the deep dermis, separated from the naevus cells above by layers of collagen, while 42% of lesions encompass the subepidermal location of the naevi and appear to be expanded naevi, although cells have morphological features of malignancy
• majority of tumors are located on the back
• mice develop malignant melanoma by 200 days of age after a single neonatal UVB dose
• melanocyte migration from the follicular outer root sheath into the epidermis after neonatal UV radiation is normal

pigmentation
• mice develop dermal melanocyte proliferations that are similar to superficial cogenital naevi
• neonates exhibit a higher number of dermal melanocytes

integument
• naevi are nearly always observed immediately beneath the epidermis in a band-like distribution, reminiscent of naevus cells, above lesions
• spontaneous development of malignant melanoma by 300 days of age in all mice
• malignant melanomas have the appearance of nodular lesions and tumors show larger and more pleomorphic nuclei, abundant cytoplasm and numerous multinucleated giant cells and low levels of Ki-67 staining
• two distinct malignant melanoma subtypes are seen: 55% of melanomas are in the deep dermis, separated from the naevus cells above by layers of collagen, while 42% of lesions encompass the subepidermal location of the naevi and appear to be expanded naevi, although cells have morphological features of malignancy
• majority of tumors are located on the back

cellular
• mice develop dermal melanocyte proliferations that are similar to superficial cogenital naevi


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/19/2019
MGI 6.13
The Jackson Laboratory