About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5644499
Allelic
Composition
Tg(MMTV-PyVT)#Mul/0
Genetic
Background
B6.FVB-Tg(MMTV-PyVT)#Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop mammary carcinomas with 100% penetrance
• primary tumors develop at varying ages, with the first masses seen between 90-120 days of age
• tumors comprise primarily of solid, glandular and acinar forms and often contain cystic areas
• progression to pulmonary metastases is seen in more than 95% of mice more than 130 days of age

immune system
• B cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
• splenocytes from mice with tumor loads show reduced proliferative responses in response to mitogens
• enlarged spleen in mice with tumors, with mice with the highest tumor burdens having the largest spleens
• percentage of tumor-infiltrating Treg cells is increased
• percentage of macrophage-like populations and myeloid cells in the spleen increase with increasing tumor load, with a corresponding decrease in the percentage of T cells
• however, percentage of NKT cells in the spleen is similar to controls
• total number of splenocytes increases progressively with increasing tumor burden
• T cells from CD3/CD28-stimulated splenocytes from tumor-bearing mice produce lower levels of IFN-gamma
• T cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
• tumor-bearing mice show increased serum levels of pro-inflammatory cytokines MCP-1 and TNF-alpha
• total number of lymph node cells in tumor-draining lymph nodes increases progressively until a total tumor burden between 8 and 12 cm3 is reached, after which a decrease in lymph node cell numbers is seen
• increase in the percentages of B cells within the tumor-draining lymph nodes of mice with extensive tumor loads
• however, percentage of NKT cells in the tumor-draining lymph nodes is similar to controls

homeostasis/metabolism
• tumor-bearing mice show increased serum levels of pro-inflammatory cytokines MCP-1 and TNF-alpha

hematopoietic system
• B cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
• splenocytes from mice with tumor loads show reduced proliferative responses in response to mitogens
• enlarged spleen in mice with tumors, with mice with the highest tumor burdens having the largest spleens
• percentage of tumor-infiltrating Treg cells is increased
• myeloid cells in the spleen are increased in tumor-bearing mice
• percentage of macrophage-like populations and myeloid cells in the spleen increase with increasing tumor load, with a corresponding decrease in the percentage of T cells
• however, percentage of NKT cells in the spleen is similar to controls
• total number of splenocytes increases progressively with increasing tumor burden
• T cells from CD3/CD28-stimulated splenocytes from tumor-bearing mice produce lower levels of IFN-gamma
• T cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS

cellular
• B cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
• T cells from mice with tumors show a reduction in proliferation in response to stimulation with ConA and LPS
• splenocytes from mice with tumor loads show reduced proliferative responses in response to mitogens

endocrine/exocrine glands
• mice develop mammary carcinomas with 100% penetrance
• primary tumors develop at varying ages, with the first masses seen between 90-120 days of age
• tumors comprise primarily of solid, glandular and acinar forms and often contain cystic areas

integument
• mice develop mammary carcinomas with 100% penetrance
• primary tumors develop at varying ages, with the first masses seen between 90-120 days of age
• tumors comprise primarily of solid, glandular and acinar forms and often contain cystic areas

growth/size/body
• enlarged spleen in mice with tumors, with mice with the highest tumor burdens having the largest spleens

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:147923


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory