Phenotypes Associated with This Genotype

Genotype
MGI:5637814

• Allelic Composition: Lgals3^tm1Ftl/Lgals3^tm1Ftl
• Genetic Background: involves: 129S2/SvPas * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver inflammation ( J:221030 )

♂ • neutrophil aggregation in the liver lobules and lymphocyte-predominant lobular inflammation with or without portal inflammation are seen at varying degrees after 15 months of age

♂ • necroinflammation worsens with age focal hepatic necrosis

abnormal liver morphology ( J:116073 , J:221030 )

♂ • neutrophil infiltration, Mallory bodies, and megamitochondria are seen occasionally in 6 month old mice (J:116073)

♂ • 40%, 50%, and 100% of mice exhibit dysplastic liver nodules of various sizes at 15, 20, and 25 months of age, respectively (J:221030)

♂ • nodules have no capsule and exhibit increased cellularity with irregular hepatocellular arrangement and cellular atypia is frequently seen (J:221030)

focal hepatic necrosis ( J:116073 , J:221030 )

♂ • focal and/or spotty necrosis are seen occasionally in 6 month old mice (J:116073)

♂ (J:221030)

increased liver weight ( J:116073 )

♂ • the liver weight per body weight ratio is increased at 6 months of age

increased liver triglyceride level ( J:116073 )

♂ • in 6 month old mice

abnormal hepatocyte morphology ( J:116073 )

♂ • hepatocytes of 6 month old mice show ballooning degeneration and scattered lipogranuloma

Mallory bodies ( J:116073 )

♂ • Mallory bodies are seen occasionally in 6 month old mice

hepatic steatosis ( J:116073 , J:221030 )

♂ • livers show mild to severe macrovesicular and microvesicular fatty change which is enhanced in the perivenular area at 6 months of age (J:116073)

♂ • the macro- and micro-vacuoles of hepatocytes contain lipids at 6 months of age (J:116073)

♂ • mice develop features similar to nonalcoholic fatty liver disease that progresses to nonalcoholic steatohepatitis (J:221030)

♂ • the degree of steatosis decreases with age, fat vesicles accumulating in hepatocytes become smaller in size and the distribution diffused in the liver parenchyma (J:221030)

liver fibrosis ( J:221030 )

♂ • 40%, 75%, and 100% of mice develop mild to moderate perivenular and pericellular fibrosis at 15, 20, and 25 months of age, respectively

increased hepatocellular carcinoma incidence ( J:221030 )

♂ • inner nodules showing thick trabecular arrangement and pseudoglandular pattern are indicative of moderately differentiated hepatocellular carcinoma

homeostasis/metabolism

increased circulating alanine transaminase level ( J:116073 )

♂ • in 6 month old mice

increased liver triglyceride level ( J:116073 )

♂ • in 6 month old mice

cellular

focal hepatic necrosis ( J:116073 , J:221030 )

♂ • focal and/or spotty necrosis are seen occasionally in 6 month old mice (J:116073)

♂ (J:221030)

oxidative stress ( J:116073 )

♂ • lipid peroxide levels are higher in the liver at 2 and 6 months of age, indicating oxidative stress

immune system

liver inflammation ( J:221030 )

♂ • neutrophil aggregation in the liver lobules and lymphocyte-predominant lobular inflammation with or without portal inflammation are seen at varying degrees after 15 months of age

♂ • necroinflammation worsens with age focal hepatic necrosis

neoplasm

increased hepatocellular carcinoma incidence ( J:221030 )

♂ • inner nodules showing thick trabecular arrangement and pseudoglandular pattern are indicative of moderately differentiated hepatocellular carcinoma

growth/size/body

increased liver weight ( J:116073 )

♂ • the liver weight per body weight ratio is increased at 6 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
steatotic liver disease		DOID:9452	OMIM:228100	J:116073 , J:221030