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Phenotypes Associated with This Genotype
Genotype
MGI:5637814
Allelic
Composition
Lgals3tm1Ftl/Lgals3tm1Ftl
Genetic
Background
involves: 129S2/SvPas * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgals3tm1Ftl mutation (2 available); any Lgals3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• the liver weight per body weight ratio is increased at 6 months of age

liver/biliary system
• neutrophil aggregation in the liver lobules and lymphocyte-predominant lobular inflammation with or without portal inflammation are seen at varying degrees after 15 months of age
• necroinflammation worsens with age focal hepatic necrosis
• neutrophil infiltration, Mallory bodies, and megamitochondria are seen occasionally in 6 month old mice (J:116073)
• 40%, 50%, and 100% of mice exhibit dysplastic liver nodules of various sizes at 15, 20, and 25 months of age, respectively (J:221030)
• nodules have no capsule and exhibit increased cellularity with irregular hepatocellular arrangement and cellular atypia is frequently seen (J:221030)
• focal and/or spotty necrosis are seen occasionally in 6 month old mice (J:116073)
(J:221030)
• the liver weight per body weight ratio is increased at 6 months of age
• in 6 month old mice
• hepatocytes of 6 month old mice show ballooning degeneration and scattered lipogranuloma
• Mallory bodies are seen occasionally in 6 month old mice
• livers show mild to severe macrovesicular and microvesicular fatty change which is enhanced in the perivenular area at 6 months of age (J:116073)
• the macro- and micro-vacuoles of hepatocytes contain lipids at 6 months of age (J:116073)
• mice develop features similar to nonalcoholic fatty liver disease that progresses to nonalcoholic steatohepatitis (J:221030)
• the degree of steatosis decreases with age, fat vesicles accumulating in hepatocytes become smaller in size and the distribution diffused in the liver parenchyma (J:221030)
• 40%, 75%, and 100% of mice develop mild to moderate perivenular and pericellular fibrosis at 15, 20, and 25 months of age, respectively
• inner nodules showing thick trabecular arrangement and pseudoglandular pattern are indicative of moderately differentiated hepatocellular carcinoma

homeostasis/metabolism
• in 6 month old mice

cellular
• focal and/or spotty necrosis are seen occasionally in 6 month old mice (J:116073)
(J:221030)
• lipid peroxide levels are higher in the liver at 2 and 6 months of age, indicating oxidative stress

immune system
• neutrophil aggregation in the liver lobules and lymphocyte-predominant lobular inflammation with or without portal inflammation are seen at varying degrees after 15 months of age
• necroinflammation worsens with age focal hepatic necrosis

neoplasm
• inner nodules showing thick trabecular arrangement and pseudoglandular pattern are indicative of moderately differentiated hepatocellular carcinoma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
fatty liver disease DOID:9452 OMIM:228100
J:116073 , J:221030


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory