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Phenotypes Associated with This Genotype
Genotype
MGI:5635492
Allelic
Composition
H2dlAb1-Ea/H2dlAb1-Ea
Tg(HLA-DRA,HLA-DRB5*0101)hiKito/0
Tg(TRATL3A6,TRBTL3A6)#Kito/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2dlAb1-Ea mutation (12 available); any H2 mutation (274 available)
Tg(HLA-DRA,HLA-DRB5*0101)hiKito mutation (0 available)
Tg(TRATL3A6,TRBTL3A6)#Kito mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice show greater numbers of Th1-, Th17-, and GM-CSF+-expressing CD4 T cells in response to MBP (83-99)
• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE
• in both induced and spontaneous EAE mice
• in both induced and spontaneous EAE mice
• mice show an increased production of IFN-gamma, IL-17, and GM-CSF cytokines in response to MBP (83-99)
• mice that spontaneously develop EAE exhibit an increased production of IFN-gamma, IL-7 and GM-CSF cytokines in the CNS
• in both induced and spontaneous EAE mice
• in both induced and spontaneous EAE mice
• mice rarely exhibit experimental autoimmune encephalitis (EAE) when immunized with CFA or pertussis alone, but immunization with MBP (83-99) in CFA with pertussis elicits encephalitis in 90% of mice
• mice that develop either induced or spontaneous EAE show mild redicultis of the spinal nerve root and mild neuritis of the cranial nerve root in less than 50% of sections examined
• mice that develop either induced or spontaneous EAE show severe/moderate inflammation in the spinal cord (meningomyelitis), with lesser involvement of the brainstem and infiltrates contain predominantly CD4+ T cells and mononuclear cells, as well as polymorphnuclear leukocytes/granulocytes
• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age

behavior/neurological
• both induced and spontaneous EAE mice develop ascending motor deficits

hematopoietic system
• mice show greater numbers of Th1-, Th17-, and GM-CSF+-expressing CD4 T cells in response to MBP (83-99)
• mice that spontaneously develop EAE have greater numbers of MBP-specific Th1, and GM-CDF+ CD4+ T cells in the CNS during the course of spontaneous EAE
• in both induced and spontaneous EAE mice
• in both induced and spontaneous EAE mice

nervous system
• mice that develop either induced or spontaneous EAE show severe/moderate inflammation in the spinal cord (meningomyelitis), with lesser involvement of the brainstem and infiltrates contain predominantly CD4+ T cells and mononuclear cells, as well as polymorphnuclear leukocytes/granulocytes
• mice develop spontaneous experimental autoimmune encephalitis (EAE) with an incidence of 4.5%; onset of disease is around 10 weeks of age
• both induced and spontaneous EAE mice exhibit swollen axons throughout the spinal cord
• both induced and spontaneous EAE mice exhibit degenerating neurons throughout the spinal cord
• both induced and spontaneous EAE mice exhibit loss of axons

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
J:189816


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory