Phenotypes for Bscl2 Tg(Fabp4-cre)1Rev MGI:5629954 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bscl2^tm1.1Gliu/Bscl2^tm1.1Gliu Tg(Fabp4-cre)1Rev/0
Genetic Background	involves: 129 * 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bscl2^tm1.1Gliu mutation (0 available); any Bscl2 mutation (33 available)
Tg(Fabp4-cre)1Rev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

lipodystrophy ( J:211072 )

• males develop progressive lipodystrophy

homeostasis/metabolism

increased circulating insulin level ( J:211072 )

• increase in fed plasma insulin levels

increased circulating cholesterol level ( J:211072 )

reproductive system

reproductive system phenotype ( J:211072 )

N	• males exhibit normal mating behavior and sire offspring at normal frequencies, indicating normal fertility, show normal serum FSH, LH, testosterone and estradiol levels, and exhibit normal sperm

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
male infertility		DOID:12336		J:211072

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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