Phenotypes for Pink1 Slc6a3 Tg(tetO-SNCA*A53T)E2Cai MGI:5619815 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pink1^tm1Zhzh/Pink1^tm1Zhzh Slc6a3^tm4.1(tTA)Xz/? Tg(tetO-SNCA*A53T)E2Cai/?
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1^tm1Zhzh mutation (0 available); any Pink1 mutation (42 available)
Slc6a3^tm4.1(tTA)Xz mutation (1 available); any Slc6a3 mutation (66 available)
Tg(tetO-SNCA*A53T)E2Cai mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitochondrial morphology ( J:218892 )

• 51% reduction of mitochondrial mass at 3 weeks of age

nervous system

neuronal cytoplasmic inclusions ( J:218892 )

• "mitochondrial inclusions are observed in in dopaminergic neurons beginning at 3 weeks of age

• inclusions average 4.2 um in diameter and are labeled by mitochondrial markers (COX1, SOD2)

• number of inclusions is approximately 1.4 inclusions per dopaminergic neuron

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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