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Phenotypes Associated with This Genotype
Genotype
MGI:5617944
Allelic
Composition
Ednrbtm1Ywa/Ednrbtm1Ywa
Genetic
Background
B6;129-Ednrbtm1Ywa/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrbtm1Ywa mutation (4 available); any Ednrb mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Colon crypt proliferation in Ednrbtm1Ywa/Ednrbtm1Ywa mice

digestive/alimentary system
• distal colon shows increased thickness of the mucosal layer
• total crypt length is increased distally in the colon at P7 and P18
• however, crypt length and proliferation in the proximal colon are not different from wild-type mice
• goblet cell number and size are increased in the distal (aganglionic) colon at P18
• goblet cell number and size are decreased in the proximal colon at P18
• distal colon shows increased thickness of the mucosal layer
• mice show expansion of the proliferative zone in the distal colon at P7 and P18
• mice show reduced stool water content
• transepithelial resistance is increased in the distal colon
• mice exhibit hindered transport of particles in intact mucus on colon epithelium indicating increased mucus viscosity in the distal colon and enhanced barrier properties
• however, chloride secretion from crypt enterocytes in the distal colon in response to stimulation with either carbachol or forskolin is similar to wild-type mice

endocrine/exocrine glands
• total crypt length is increased distally in the colon at P7 and P18
• however, crypt length and proliferation in the proximal colon are not different from wild-type mice
• goblet cell number and size are increased in the distal (aganglionic) colon at P18
• goblet cell number and size are decreased in the proximal colon at P18


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory