Phenotypes Associated with This Genotype

Genotype
MGI:5614265

• Allelic Composition: Tnni3k^tm1Tfo/Tnni3k^tm1Tfo; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:213546 )

N • tamoxifen-treated mice exhibit normal left ventricle function and cardiac morphometry and normal left ventricular remodeling after permanent occlusion myoinfarction

abnormal myocardial fiber physiology ( J:213546 )

• decreased cell death in tamoxifen-treated mice following ischemic injury

abnormal response to cardiac infarction ( J:213546 )

• following ischemic/reperfusion injury, tamoxifen-treated mice exhibit decreased infarct size and cardiomyocyte cell death compared with wild-type mice

• however, normal left ventricular remodeling after permanent occlusion myoinfarction

decreased myocardial infarct size ( J:213546 )

• in tamoxifen-treated mice following ischemic/reperfusion injury

homeostasis/metabolism

abnormal response to cardiac infarction ( J:213546 )

• following ischemic/reperfusion injury, tamoxifen-treated mice exhibit decreased infarct size and cardiomyocyte cell death compared with wild-type mice

• however, normal left ventricular remodeling after permanent occlusion myoinfarction

decreased myocardial infarct size ( J:213546 )

• in tamoxifen-treated mice following ischemic/reperfusion injury