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Phenotypes Associated with This Genotype
Genotype
MGI:5614089
Allelic
Composition
Rb1tm2.1Fad/Rb1tm2.1Fad
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2.1Fad mutation (1 available); any Rb1 mutation (106 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• half of mice die after birth
• defective skeletal muscle correlates with poor survival
• however, surviving mice have normal life expectancy

respiratory system
• some mice struggle to breath at birth

muscle
• at E18.5 without an increase in proliferation
• atrophy is observed in the diaphragm
• defective skeletal muscle correlates with poor survival
• however, the defect is unlikely to be caused by cell cycle arrest

integument
• with additional layers of epithelium
• however, female mice are able to nurse their pups

digestive/alimentary system
N
• intestinal epithelium is normal

cellular
N
• under serum deprivation conditions, asynchronous mouse embryonic fibroblasts exhibit normal cell cycle progression and proliferation rates

nervous system
N
• pituitary glands exhibit no evidence of hyperplasia at 8 to 11 months

neoplasm
N
• mice are tumor free beyond 1.5 years of life

endocrine/exocrine glands
• with additional layers of epithelium
• however, female mice are able to nurse their pups


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory