Phenotypes Associated with This Genotype

Genotype
MGI:5613396

• Allelic Composition: Bmal1^tm1.2Shbi/Bmal1^tm1.2Shbi
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

increased skeletal muscle triglyceride level ( J:177865 )

♂ • in mice fed a high fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:177865 )

♂N • in the presence of excess insulin, mice exhibit normal blood glucose clearance rate

decreased susceptibility to diet-induced obesity ( J:177865 )

♂ • mice fed a high fat diet exhibit almost constant weight after 4 weeks unlike wild-type mice that continue to gain weight

increased respiratory quotient ( J:177865 )

♂ • under both light/dark and dark/dark conditions

abnormal glucose homeostasis ( J:177865 )

♂ • 2 times the liver insulin levels observed in wild-type mice

decreased insulin secretion ( J:177865 )

♂ • after glucose or glibenclamide administration

♂ • however, liver insulin content is increased

hyperglycemia ( J:177865 )

♂

decreased circulating insulin level ( J:177865 )

♂ • during a glucose tolerance test

abnormal gluconeogenesis ( J:177865 )

♂

impaired glucose tolerance ( J:177865 )

♂

abnormal lipid level ( J:177865 )

♂ • reduced triglyceride to cholesterol molar ratio

♂ • increased LDL cholesterol to HDL cholesterol ratio

decreased circulating HDL cholesterol level ( J:177865 )

♂ • in mice are fed standard chow

increased circulating cholesterol level ( J:177865 )

♂ • in mice are fed a high fat diet

increased circulating HDL cholesterol level ( J:177865 )

♂ • in mice are fed a high fat diet

increased circulating LDL cholesterol level ( J:177865 )

♂ • in mice are fed standard chow or a high fat diet

increased circulating VLDL cholesterol level ( J:177865 )

♂ • in mice are fed standard chow or a high fat diet

increased circulating free fatty acids level ( J:177865 )

♂ • when mice are fed a high fat diet

decreased circulating VLDL triglyceride level ( J:177865 )

♂ • in mice are fed standard chow

increased circulating triglyceride level ( J:177865 )

♂ • in mice fed standard chow and more so in mice fed a high fat diet

♂ • increased circulating LDL and HDL triglyceride in mice fed a standard diet or a high fat diet

increased liver triglyceride level ( J:177865 )

♂ • in mice fed a high fat diet

increased skeletal muscle triglyceride level ( J:177865 )

♂ • in mice fed a high fat diet

growth/size/body

decreased body weight ( J:177865 )

♂ • when mice are fed standard chow

decreased susceptibility to diet-induced obesity ( J:177865 )

♂ • mice fed a high fat diet exhibit almost constant weight after 4 weeks unlike wild-type mice that continue to gain weight

adipose tissue

decreased total body fat amount ( J:177865 )

♂ • after 5 weeks on a high fat diet

decreased white fat cell size ( J:177865 )

♂ • in mice are fed a high fat diet

behavior/neurological

behavior/neurological phenotype ( J:177865 )

♂N • mice exhibit normal food intake whether fed standard chow or a high fat diet

abnormal locomotor circadian rhythm ( J:177865 )

♂ • loss of circadian rhythm in locomotor activity

liver/biliary system

increased liver triglyceride level ( J:177865 )

♂ • in mice fed a high fat diet

increased susceptibility to diet-induced hepatic steatosis ( J:177865 )

♂ • in mice fed a high fat diet

endocrine/exocrine glands

enlarged pancreatic islets ( J:177865 )

♂ • increased area at 44 weeks

♂ • however, area is normal at 12 weeks

decreased insulin secretion ( J:177865 )

♂ • after glucose or glibenclamide administration

♂ • however, liver insulin content is increased

increased sebum secretion ( J:177865 )

♂ • excess sebum in mice fed a high fat diet

integument

increased sebum secretion ( J:177865 )

♂ • excess sebum in mice fed a high fat diet